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Effectivity of puncture method for intervertebral disc degeneration animal models: review article
Intervertebral disk degeneration (IDD) is a chronic condition brought on by various factors and mechanisms that have been linked to many deaths and illnesses. The causes of IDD involve multiple processes, including genetics, stress, cellular aging, and changes in nutrition due to the limited blood supply. Animal modelsplay acrucialrole inbiomedical research andthe selectionofthesemodels is based on many considerations, including the need for similarities in structure and function with humans. This is important because the etiology and pathogenesis of IDDare complex.Finding theright animal model is notan easy task. In addition to having similarities to humans, these models should also be reliable, reproducible, cost effective, and easy to maintain. One common method of inducing IDD in animal models is need lepuncture.This method is less invasive and time-consuming compared too the methods and allows for precise control over the extent and location of the injury.
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